Endocrine Abstracts

Objective: Oxidative stress has been implicated in the pathogenesis of hyperthyroidism, and its complications. Advanced glycation end products (AGEs), compounds derived from non-enzymatic transformation of macromolecules, are able to increase oxidative stress and promote inflammation and are increased in several oxidative stress-related disorders, including autoimmune thyroiditis. In the same diseases, the activity of paraoxonase-1 (PON-1), an anti-oxidant enzyme protecting ag...